Dress syndrome associated with antituberculous drugs

Abstract

A 17 years-old woman diagnosed of pulmonary tuberculosis received rifampicin, isoniazid, pyrazinamide and ethambutol. Four weeks later, she presented a skin rash, conjunctival jaundice, fever and pruritus, eosinophilia and elevated liver enzymes. With the diagnosis of DRESS syndrome, the TB treatment was stopped and corticosteroids and antihistamines were administered. The patient developed multi-organ failure and died two days after admission.