Eradication of Helicobacter pylori with first-line triple therapy, 10 days versus 14 days

Authors

  • María Nelly Manrique-Lemus Hospital EsSalud Uldarico Rocca Fernández
  • José Luis Rojas-Vilca Universidad Peruana Cayetano Heredia
  • Mario Salomón Valdivia-Roldán línica Centenario Peruano Japonesa
  • Alaciel Melissa Palacios-Guillén Hospital Nacional Daniel Alcides Carrión del Callao

DOI:

https://doi.org/10.36393/spmi.v33i4.560

Keywords:

Helicobacter pylori, treatment, dyspepsia

Abstract

 Objective: To determine if the eradication rate of Helicobacter pylori with first line triple therapy for 14 days is better than with 10 days. Material and methods: Retrospective cohort study. It was reviewed medical records of the patients with dyspepsia and upper digestive endoscopy with a positive H. pylori biopsy, who received triple therapy with amoxicillin, clarithromycin and omeprazole for 10 or 14 days. Eradication was defined by the 13C-UBT breath test, 4 to 6 weeks after treatment. Results: It was evaluated 381 patients, 207 received treatment for 10 days and 174 for 14 days. The average age was 49 ± 13.9(15 to 82) years. The female sex was predominating (69,8%). The eradication rate of H. pylori in the 10-day and 14-day treatment group was 79, 7% and 82, 2% respectively (risk ratio, 1.03; 95% confidence interval, 0.94-1.14; p=0,541). Adverse events were reported in 75,1% and 77,3% of the 10 and 14 days group respectively (p= 0,634). Conclusion: First-line triple therapy for 14 days for H. pylori eradication was not better than 10 days’ therapy. The eradication rate was poor and unacceptable respectively.

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Published

2020-12-19

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Section

Trabajo original

How to Cite

Eradication of Helicobacter pylori with first-line triple therapy, 10 days versus 14 days. (2020). Revista De La Sociedad Peruana De Medicina Interna, 33(4), 138-145. https://doi.org/10.36393/spmi.v33i4.560

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