Langerhans cell pulmonary histiocytosis in a non-smoking male

Abstract

Langerhans cell histiocytosis is a rare neoplastic disorder of unknown etiology. A 23-year-old non-smoker who consulted for fever and constitutional symptoms; and, chest images showed multiple bilateral nodular lesions. The histopathological study showed infiltration of histiocytic cells with S100 (+), CD1a (+), intraalveolar macrophages CD68(+), confirming the diagnosis of pulmonary histiocytosis of Langerhans cells. He was treated with corticosteroids, obtaining a favorable clinical and imaging response.